ID (ISN) del documento | 53212 |
Número CIS |
90-217 |
ISSN - Título de la serie |
0007-1072 - British Journal of Industrial Medicine |
Año |
1989 |
Número de serie |
|
Autor(es) |
Roels H.A., Lauwerys R.R., Buchet J.P., Bernard A.M., Vos A., Oversteyns M. |
Título |
Health significance of cadmium induced renal dysfunction: A five year follow up |
Información bibliográfica |
Nov. 1989, Vol.46, No.11, p.755-764. Illus. 41 ref. |
Resumen |
To assess the health significance of early renal changes after chronic exposure to cadmium, 23 workers removed from exposure because of the discovery of an increased urinary excretion of β2-microglobulin or retinol binding protein, or both, have been examined once a year for five years. Eight of these workers had also an increased level of albuminuria. These workers had been exposed to cadmium for 6-41.7 years (mean 25 years). It was confirmed that proteinuria induced by cadmium is irreversible. The most important finding, however, is a significant increase of creatinine and β2-microglobulin concentrations in serum with time, indicating a progressive reduction of the glomerular filtration rate despite removal from exposure. Serum alkaline phosphatase activity also increases significantly with time. In conclusion, the present study indicates that early renal changes induced by cadmium should be regarded as adverse effects; they are predictive of an exacerbation of the age related decline in the glomerular filtration rate. |
Descriptores (primarios) |
disfunción renal; industrias de metales no ferrosos; cadmio; exposición de larga duración |
Descriptores (secundarios) |
excreción urinaria; tests de exposición; observación de larga duración; proteinuria |
Tipo de documento |
D - Artículos periódicos |
Tema(s) |
Patología profesional
|
Broad subject area(s) |
Riesgos químicos
|
Navegación por categoria(s) |
Diseases of the kidney and the urinary system Smelting and refining operations Cadmium and compounds Inorganic substances
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