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Base de datos CISDOC

ID (ISN) del documento53212
Número CIS 90-217
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1989
Número de serie
Autor(es) Roels H.A., Lauwerys R.R., Buchet J.P., Bernard A.M., Vos A., Oversteyns M.
Título Health significance of cadmium induced renal dysfunction: A five year follow up
Información bibliográfica Nov. 1989, Vol.46, No.11, p.755-764. Illus. 41 ref.
Resumen To assess the health significance of early renal changes after chronic exposure to cadmium, 23 workers removed from exposure because of the discovery of an increased urinary excretion of β2-microglobulin or retinol binding protein, or both, have been examined once a year for five years. Eight of these workers had also an increased level of albuminuria. These workers had been exposed to cadmium for 6-41.7 years (mean 25 years). It was confirmed that proteinuria induced by cadmium is irreversible. The most important finding, however, is a significant increase of creatinine and β2-microglobulin concentrations in serum with time, indicating a progressive reduction of the glomerular filtration rate despite removal from exposure. Serum alkaline phosphatase activity also increases significantly with time. In conclusion, the present study indicates that early renal changes induced by cadmium should be regarded as adverse effects; they are predictive of an exacerbation of the age related decline in the glomerular filtration rate.
Descriptores (primarios) disfunción renal; industrias de metales no ferrosos; cadmio; exposición de larga duración
Descriptores (secundarios) excreción urinaria; tests de exposición; observación de larga duración; proteinuria
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Diseases of the kidney and the urinary system
Smelting and refining operations
Cadmium and compounds
Inorganic substances