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Base de datos CISDOC

ID (ISN) del documento48768
Número CIS 87-1353
ISSN - Título de la serie 0098-4108 - Journal of Toxicology and Environmental Health
Año 1987
Número de serie
Autor(es) Governa M., Calisti R., Coppa G., Tagliavento G., Colombi A., Troni W.
Título Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies in workers exposed to hexane
Información bibliográfica 1987, Vol.20, No.3, p.219-228. 26 ref.
Resumen 40 shoe factory workers who were exposed to hexane were investigated to see if there was a correlation between electroneuromyographic changes indicative of neuropathy and urinary excretion of the metabolic products of n-hexane and its isomers. 2,5-Hexanedione and γ-valerolactone were discovered in all cases, while 2-hexanol was found in 11 cases. 2,5-Hexanedione was the main metabolite in 39 cases. Metabolic products of cyclohexane were present in about one-fifth of the cases, while trichloroethanol, a metabolic product of trichloroethylene, was nearly always present, all at very low concentrations. Electromyographic abnormalities significant for early detection of toxic polyneuropathy were found in 14 cases. A statistically significant correlation of the electroneuromyographic scoring with the urinary metabolites was observed only for 2,5-hexanedione and γ-valerolactone. Since γ-valerolactone is probably not a true metabolite of n-hexane, the results support the hypothesis that polyneuropathies in shomakers are due to 2,5-hexanedione. For practical purposes the urinary concentration of 2,5-hexanedione can serve as a predictive measurement for early detection of neurotoxic lesions at preclinical stages.
Descriptores (primarios) hexanediona-2,5; hexano; industria del calzado; enfermedades del sistema nervioso periférico; valoración de la exposición; excreción urinaria
Descriptores (secundarios) gamma-valerolactona; valoración estadística; electroneuromiografía; metabolitos urinarios
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Footwear, leather and fur industry
Aliphatic and alicyclic hydrocarbons
Exposure evaluation
Diseases of the nervous system