| ID (ISN) del documento | 47007 |
| Número CIS |
86-1862 |
| ISSN - Título de la serie |
0096-1736 - Journal of Occupational Medicine |
| Año |
1986 |
| Número de serie |
|
| Autor(es) |
Skipper P.L., Bryant M.S., Tannenbaum S.R., Groopman J.D. |
| Título |
Analytical methods for assessing exposure to 4-aminobiphenyl based on protein adduct formation |
| Información bibliográfica |
Aug. 1986, Vol.28, No.8, p.643-646. Illus. 8 ref. |
| Resumen |
Past studies with animals have demonstrated that 4-aminobiphenyl (ABP) administration results in the formation of appreciable amounts of adducts between the carcinogen and both serum albumin and haemoglobin. The haemoglobin adduct is relatively stable in vivo, but may be readily hydrolysed in vitro to regenerate ABP. The formation of this adduct reflects a mixed-function-oxidase-mediated metabolic pathway operating directly on the amine. The predominant albumin adduct, 3-(tryptophan-N1-yl)-4-acetylaminobiphenyl, reflects the contribution of N-acetyltransferase activity as well as mixed-function-oxidase activity to the overall metabolism. The simultaneous measurement of these 2 different adducts thus offers an opportunity to investigate the role of both ABP and acetylator phenotype in bladder carcinogenesis. An analytical method, using gas chromatography coupled with electron capture detection, was developed to quantitate ABP adducted to haemoglobin. |
| Descriptores (primarios) |
amino-4 bifenilo; tests de exposición; dosificación en la sangre; tumor de vejiga |
| Descriptores (secundarios) |
descripción del procedimiento |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Aromatic amines
Biological monitoring
Diseases of the kidney and the urinary system
|
