| ID (ISN) del documento | 46732 |
| Número CIS |
86-1548 |
| ISBN(s) |
91-7464-234-0 |
| Año |
1984 |
| Número de serie |
Arbete och Hälsa 1984:41
|
| Autor(es) |
Øvrebø S. |
| Título |
Nordic Expert Group for Documentation of Occupational Exposure Limits - 53. Methanol |
| Título original |
Nordisk ekspertgruppe for grenseverdidokumentasjon - 53. Metanol [en noruego] |
| Información bibliográfica |
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1984. 45p. 104 ref. |
| Resumen |
Review of the literature on methanol as background to discussions on occupational exposure limits. Exposure of man to extremely high concentrations of methanol affects the central nervous system and causes acidosis. Blindness is the most serious complication. Adverse effects on the eyes is mainly confined to the optic nerve as optic disk oedema. The putamen appears to be a particularly susceptible part of the brain in methanol poisoning. However, the clinical consequences of this sensitivity are unknown. Formic acid has been shown to inhibit oxidative phosphorylation. This inhibition is believed to be one of the mechanisms by which methanol exerts its toxic effects. Knowledge is limited regarding the effects of exposure to methanol at low concentrations for long periods of time. The following effects have been reported: blurred vision, eye irritation, headache, nausea and dizziness. It is recommended that an exposure limit be based on these effects. |
| Descriptores (primarios) |
efectos neurotóxicos; efectos biológicos; toxicología; metanol |
| Descriptores (secundarios) |
revisión bibliográfica; nota informativa; determinación de los límites de la exposición |
| Tipo de documento |
E - Libros, informes, actas |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Diseases of the nervous system
Alcohols
|
