| ID (ISN) del documento | 42495 |
| Número CIS |
84-1394 |
| ISSN - Título de la serie |
0105-1873 - Contact Dermatitis |
| Año |
1983 |
| Número de serie |
|
| Autor(es) |
Rycroft R.J.C. |
| Título |
Allergic contact dermatitis from a novel diamino intermediate, 5-((2-aminoethyl)thiomethyl)-N,N-dimethyl-2-furanmethanamine, in laboratory synthesis |
| Información bibliográfica |
Nov. 1983, Vol.9, No.6, p.456-458. Illus. |
| Resumen |
Half of the 12 chemists working on the development of a new pharmaceutical product developed rashes as a result of exposure to the title compound. The case of one of these workers is described in detail. Patch testing showed that the final product was not allergenic. The unsubstituted amino group of the 2-aminoethyl moiety is apparently essential for the title compound's activity as a hapten. Although the chemists working with the compound wore rubber gloves, the occurrence of new cases of dermatitis was halted only by transfer of the synthesis to a pilot plant with a completely closed system. |
| Descriptores (primarios) |
furano y derivados; alergenos; industria farmacéutica; alergias cutáneas; eczema; aminas |
| Descriptores (secundarios) |
estudio de caso; ((amino-2 etil)tiometil)-5 n,n-dimetilfuranmetil |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Patología profesional
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Pharmaceutical industry
Alergias
Skin diseases
Heterocyclic compounds
|
