ILO Home
Volver a la página de entrada
Site map | Contact us English | Français

Base de datos CISDOC

ID (ISN) del documento40427
Número CIS 83-1654
ISSN - Título de la serie 0140-6736 - Lancet
Año 1982
Número de serie
Autor(es) Cartwright R.A., Rogers H.J., Barham-Hall D., Glashan R.W., Ahmad R.A., Higgins E., Kahn M.A.
Título Role of N-acetyltransferase phenotypes in bladder carcinogenesis: A pharmacogenetic epidemiological approach to bladder cancer
Información bibliográfica 16 Oct. 1982, Vol.II, No.8303, p.842-846. 18 ref.
Resumen A large excess of patients with bladder cancer who have been exposed to N-substituted aryl compounds in production of dye intermediates have the slow phenotype of the enzyme N-acetyltransferase. Acetylator phenotyping in hospital patients with bladder cancer and controls is reported. Clerical workers and engineers using machine oils had slow-acetylator frequencies that were not significantly different from controls. All but 1 of 23 dye workers were slow acetylators. The results were highly significant. It is suggested that acetylator status could be used to identify susceptible individuals in potentially hazardous occupations.
Descriptores (primarios) aminas aromáticas; actividad enzimática; industria de los colorantes; sensibilidad individual; tumor de vejiga
Descriptores (secundarios) substancias cancerígenas; estudio comparado; exámenes médicos de contrato
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s)
Navegación por categoria(s) Blood diseases
Aromatic amines
Chemical industry
Diseases of the kidney and the urinary system