| ID (ISN) del documento | 40237 |
| Número CIS |
83-1387 |
| ISSN - Título de la serie |
Gigiena truda i professional'nye zabolevanija |
| Año |
1981 |
| Número de serie |
|
| Autor(es) |
Izrajlet L.I., Ustinenko A.N., Silkane V.S. |
| Título |
Toxicological characteristics of barbituric and thiobarbituric acids |
| Título original |
Toksikologičeskaja harakteristika barbiturovoj i tiobarbiturovoj kislot [en ruso] |
| Información bibliográfica |
May 1981, No.5, p.50-51. 3 ref. |
| Resumen |
Animal experiments were undertaken to determine the toxicity, risk potential and tentative safe exposure level of barbituric and thiobarbituric acids, which are handled in the pharmaceutical industry. Barbituric acid did not affect the mucous membranes of the eye and showed no cumulative effect. Repeated administration of barbituric acid over a period of a month produced some morphological changes in the liver and kidney. Barbituric acid had a depilatory effect when rubbed into the skin. A tentative TLV of 5mg/m3 is proposed. The behaviour of thiobarbituric acid was very similar. It affected the spleen as well as the liver and kidney on repeated administration, and sensitised the skin to subsequent application. A tentative TLV of 2mg/m3 is proposed. The LD50 of both compounds was greater than 5000mg/kg for all animals tested. |
| Descriptores (primarios) |
valores umbrales; URSS; industria farmacéutica; ácido tiobarbitúrico; toxicología; ácido barbitúrico |
| Descriptores (secundarios) |
alergenos; efectos hepatotóxicos; efectos nefrotóxicos; investigaciones en el animal; barbituratos |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Patología profesional
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Pharmaceutical industry
Occupational exposure limits
Heterocyclic compounds
|
