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Base de datos CISDOC

ID (ISN) del documento37774
Número CIS 82-1127
ISSN - Título de la serie 0098-4108 - Journal of Toxicology and Environmental Health
Año 1981
Número de serie
Autor(es) Lamb J.C., Marks T.A., McConnell E.E., Abeywickrama K., Moore J.A.
Título Toxicity of chlorinated phenoxy acids in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6 male mice
Información bibliográfica Nov.-Dec. 1981, Vol.8, Nos.5-6, p.815-824. Illus. 11 ref.
Resumen In 4 groups of mice, in which group I were controls, group II were given daily doses of 40mg/kg 2,4-dichlorophenoxyacetic acid (2,4-D), 40mg/kg 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and 2.4µg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in feed for 8 weeks. Group III received the same doses of 2,4-D and 2,4,5-T as group II but only 0.16µg/kg TCDD and group IV received 20, 20mg/kg and 1.2µg/kg 2,4-D, 2,4,5-T and TCDD respectively. The chemical mixtures approximated the concentrations of the components of Herbicide Orange. In the treated animals liver enlargements, hepatocellular toxicity and reduced thymus size were found, and body weight gain was significantly less than that of the control animals. Recovery from liver and thymus toxicity was observed when the mice were returned to a control diet. The thymic toxicity and hepatotoxicity were related to TCDD levels while the decrease in body weight gain was more closely associated with phenoxy acid concentrations.
Descriptores (primarios) herbicidas; ácidos fenoxiacéticos; efectos biológicos; toxicología; tetraclorodibenzodioxina
Descriptores (secundarios) ácido diclorofenoxiacético; sinergismo; investigaciones en el animal; ácido triclorofenoxiacético
Tipo de documento D - Artículos periódicos
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Heterocyclic compounds
Agricultural chemicals