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Base de datos CISDOC
ID (ISN) del documento | 37774 |
Número CIS |
82-1127 |
ISSN - Título de la serie |
0098-4108 - Journal of Toxicology and Environmental Health |
Año |
1981 |
Número de serie |
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Autor(es) |
Lamb J.C., Marks T.A., McConnell E.E., Abeywickrama K., Moore J.A. |
Título |
Toxicity of chlorinated phenoxy acids in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6 male mice |
Información bibliográfica |
Nov.-Dec. 1981, Vol.8, Nos.5-6, p.815-824. Illus. 11 ref. |
Resumen |
In 4 groups of mice, in which group I were controls, group II were given daily doses of 40mg/kg 2,4-dichlorophenoxyacetic acid (2,4-D), 40mg/kg 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and 2.4µg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in feed for 8 weeks. Group III received the same doses of 2,4-D and 2,4,5-T as group II but only 0.16µg/kg TCDD and group IV received 20, 20mg/kg and 1.2µg/kg 2,4-D, 2,4,5-T and TCDD respectively. The chemical mixtures approximated the concentrations of the components of Herbicide Orange. In the treated animals liver enlargements, hepatocellular toxicity and reduced thymus size were found, and body weight gain was significantly less than that of the control animals. Recovery from liver and thymus toxicity was observed when the mice were returned to a control diet. The thymic toxicity and hepatotoxicity were related to TCDD levels while the decrease in body weight gain was more closely associated with phenoxy acid concentrations. |
Descriptores (primarios) |
herbicidas; ácidos fenoxiacéticos; efectos biológicos; toxicología; tetraclorodibenzodioxina |
Descriptores (secundarios) |
ácido diclorofenoxiacético; sinergismo; investigaciones en el animal; ácido triclorofenoxiacético |
Tipo de documento |
D - Artículos periódicos |
Tema(s) |
Agricultura, pesca, cría de ganado
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Broad subject area(s) |
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Navegación por categoria(s) |
Heterocyclic compounds Agricultural chemicals
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