| ID (ISN) del documento | 31157 |
| Número CIS |
79-674 |
| ISSN - Título de la serie |
0032-6291 - Pracovní lékařství |
| Año |
1978 |
| Número de serie |
|
| Autor(es) |
Vlčková A., Ulrich L., Alföldi J., Babinská M. |
| Título |
Protective action of disodium cromoglycate on alveolar macrophage exposed to fibrogenic silica |
| Título original |
Antideštruktivny účinok disodium chromoglykátu sledovaný na alveolárnych makrofágoch, vystavených fibrogennému SiO2 [en eslovaco] |
| Información bibliográfica |
Aug. 1978, Vol.30, No.7, p.252-255. Illus. 12 ref. |
| Resumen |
The lesions produced by fibrogenic silica, and the protection afforded by disodium cromoglycate (DSG), were studied in vitro. The number of alveolar macrophages that died when cultured with silica increased with the silica concentration. At concentrations of 1,000µg per million alveolar macrophages, all cells were dead. Treatment of the 1,000µg silica dose with 200µg DSG reduced the proportion of dead cells to 25.92%. Spectrographic studies of silica, DSG, and DSG-treated silica excluded the hypothesis of preferential linkage. DSG appears to affect the intensity of the enzyme reaction associated with phagocytosis, as the fall in acid phosphatases confirms. |
| Descriptores (primarios) |
cromoglicato disódico; agentes protectores farmacológicos; efectos fibrogénicos; polvos respirables; sílice |
| Descriptores (secundarios) |
actividad fagocitaria; macrófagos; cultivo de células; pruebas in vitro; actividad enzimática |
| Tipo de documento |
- |
| Tema(s) |
Polvos, aerosoles
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Heterocyclic compounds
|
