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Base de datos CISDOC

ID (ISN) del documento27212
Número CIS 77-1016
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 1976
Número de serie
Autor(es) Bernard A., Roels H., Hubermont G., Buchet J.P., Masson P.L., Lauwerys R.R.
Título Characterization of the proteinuria in cadmium-exposed workers.
Información bibliográfica 21 Oct. 1976, Vol.38, No.1, p.19-30. 14 ref.
Resumen The concentration of several proteins and of total amino acids was determined in the urine of 18 cadmium-exposed workers (averge exposure 28 years) and controls. The results were compared with the electrophoretic pattern of urinary proteins on agarose gel. The previous observation was confirmed that in the majority of cadmium-exposed workers with an abnormal electrophoretic pattern or increased total proteinuria, not only low-molecular-weight proteins (β2-microglobulin) but also high-molecular-weight proteins (albumin, transferrin) are excreted in greater amounts. Proteinuria is more closely related to the concentrations of albumin and orosomucoid than that of β2-microglobulin. The change in the total amino acid concentration in urine was less marked than that of protein. Determination of low- and high-molecular-weight proteins is recommended for detecting renal damage due to cadmium.
Descriptores (primarios) toxicología; cadmio; efectos nefrotóxicos; proteinuria
Descriptores (secundarios) lesiones renales; estudio comparado; electroforesis; vigilancia de la orina
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Diseases of the kidney and the urinary system
Cadmium and compounds
Inorganic substances