ID (ISN) del documento | 27071 |
Número CIS |
77-750 |
ISSN - Título de la serie |
0300-483X - Toxicology |
Año |
1976 |
Número de serie |
|
Autor(es) |
Lake B.G., Brantom P.G., Gangolli S.D., Butterworth R., Grasso P. |
Título |
Studies on the effects of orally administered di(2-ethylhexyl) phthalate in the ferret. |
Información bibliográfica |
Nov.-Dec. 1976, Vol.6, No.3, p.341-355. Illus. 14 ref. |
Resumen |
A target-organ study of the effects of this ester (DEHP, also known as DOP) was conducted in mature male albino ferrets. DEHP treatment caused a loss of body weight when administered as a 1% (w/w) diet for 14 months. Additionally, liver enlargement with associated morphological and biochemical changes were observed. These changes consisted of liver cell enlargement, lysosomal changes, dilatation of the endoplasmic reticulum and the depression of a number of marker enzyme activities. The only other tissue observed to be affected by DEHP treatment was the testes where histological evidence of tissue damage was observed in some animals. DEHP was metabolised in the ferret to derivatives of mono(2-ethylhexyl) phthalate which were excreted in the urine both unconjugated and as glucoronides. The results were compared with previous studies in the rat; DEHP is hepatotoxic in both species. |
Descriptores (primarios) |
efectos hepatotóxicos; toxicología; alteraciones enzimáticas; ftalato de bis(etilhexilo) |
Descriptores (secundarios) |
investigaciones en el animal; efectos biológicos; histopatología; efectos gonadotrópicos |
Tipo de documento |
- |
Tema(s) |
Sustancias tóxicas y peligrosas
|
Broad subject area(s) |
|
Navegación por categoria(s) |
Blood diseases Phthalates Esters and salts Genetic factors in reaction to exposures
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