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Base de datos CISDOC

ID (ISN) del documento27071
Número CIS 77-750
ISSN - Título de la serie 0300-483X - Toxicology
Año 1976
Número de serie
Autor(es) Lake B.G., Brantom P.G., Gangolli S.D., Butterworth R., Grasso P.
Título Studies on the effects of orally administered di(2-ethylhexyl) phthalate in the ferret.
Información bibliográfica Nov.-Dec. 1976, Vol.6, No.3, p.341-355. Illus. 14 ref.
Resumen A target-organ study of the effects of this ester (DEHP, also known as DOP) was conducted in mature male albino ferrets. DEHP treatment caused a loss of body weight when administered as a 1% (w/w) diet for 14 months. Additionally, liver enlargement with associated morphological and biochemical changes were observed. These changes consisted of liver cell enlargement, lysosomal changes, dilatation of the endoplasmic reticulum and the depression of a number of marker enzyme activities. The only other tissue observed to be affected by DEHP treatment was the testes where histological evidence of tissue damage was observed in some animals. DEHP was metabolised in the ferret to derivatives of mono(2-ethylhexyl) phthalate which were excreted in the urine both unconjugated and as glucoronides. The results were compared with previous studies in the rat; DEHP is hepatotoxic in both species.
Descriptores (primarios) efectos hepatotóxicos; toxicología; alteraciones enzimáticas; ftalato de bis(etilhexilo)
Descriptores (secundarios) investigaciones en el animal; efectos biológicos; histopatología; efectos gonadotrópicos
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Blood diseases
Phthalates
Esters and salts
Genetic factors in reaction to exposures