| ID (ISN) del documento | 26546 |
| Número CIS |
77-174 |
| ISSN - Título de la serie |
0041-008X - Toxicology and Applied Pharmacology |
| Año |
1976 |
| Número de serie |
|
| Autor(es) |
Rose J.Q., Ramsey J.C., Wentzler T.H., Hummel R.A., Gehring P.J. |
| Título |
The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. |
| Información bibliográfica |
May 1976, Vol.36, No.2, p.209-226. Illus. 15 ref. |
| Resumen |
This study was undertaken to elucidate the fate of TCDD in rats given a single oral dose of 1µg/kg and repeated oral doses of 0.01, 0.1 and 1µg/kg/day for 7 weeks, and to assess the propensity of TCDD to accumulate in the body. The highest concentrations of TCDD were found in the liver and fat, with lower concentrations in the kidneys, thymus and spleen. The results indicate that TCDD does not tend to accumulate in the body at the doses used, that steady-state concentrations are reached within 13 weeks and that TCDD may be altered chemically prior to its clearance from the body. |
| Descriptores (primarios) |
metabolización; toxicología; tetraclorodibenzodioxina |
| Descriptores (secundarios) |
ingestión; propiedades acumulativas; investigaciones en el animal |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Heterocyclic compounds
|
