| ID (ISN) del documento | 23857 |
| Número CIS |
75-1669 |
| ISSN - Título de la serie |
0041-008X - Toxicology and Applied Pharmacology |
| Año |
1975 |
| Número de serie |
|
| Autor(es) |
Feetam C.L., Leach R.H., Meynell M.J. |
| Título |
Lack of a clinically important interaction between warfarin and ascorbic acid. |
| Información bibliográfica |
Mar. 1975, Vol.31, No.3, p.544-547. 8 ref. |
| Resumen |
The effect of high doses of ascorbic acid on anticoagulant control with warfarin sodium was investigated in 19 patient volunteers (11 men, 8 women, aged 40-82 years, average 61 years). Total plasma warfarin concentrations and prothrombin times were measured before, during, and after 7-day periods, when doses of 3, 5, and 10g ascorbic acid were taken daily with warfarin sodium. No clinically significant antagonism of the hypoprothrombinaemic action of warfarin occurs even when the doses of ascorbic acid taken concurrently are very high, although a fall in total plasma warfarin (2-40%, mean 17.5%) was observed. |
| Descriptores (primarios) |
vitamina C; trastornos de la coagulación sanguínea; warfarina; médicamentos |
| Descriptores (secundarios) |
dosificación en la sangre; investigaciones sobre el hombre |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Blood diseases
Heterocyclic compounds
|
