ID (ISN) del documento | 22308 |
Número CIS |
75-155 |
ISSN - Título de la serie |
Gigiena truda i professional'nye zabolevanija |
Año |
1974 |
Número de serie |
|
Autor(es) |
Pavlenko G.I., Osina S.A., Voroncov R.S. |
Título |
Respiratory toxicity of triphthazine in animal experiments |
Título original |
Ingalacionnoe vozdejstvie triftazina v uslovijah ėksperimenta na životnyh [en ruso] |
Información bibliográfica |
Apr. 1974, No.4, p.27-30. 5 ref. |
Resumen |
The drug triphthazine is a piperazine derivative of phenothiazine. Studies in albino rats have shown that inhalation of 1.5mg/m3 of triphthazine has an effect on the central nervous system. Chronic exposure of the animals to 0.06mg/m3 produces loss of bodyweight, elevated rectal temperature, a fall in leucocyte and erythrocyte levels, slowing of the respiratory rate and a considerable increase in diuresis. On the basis of the results obtained, the authors recommend the adoption of a threshold limit value of 0.01mg/m3. |
Descriptores (primarios) |
efectos neurotóxicos; toxicología; triftacina; médicamentos |
Descriptores (secundarios) |
valores umbrales; exposición de larga duración; investigaciones en el animal; polaquiuria |
Tipo de documento |
- |
Tema(s) |
Sustancias tóxicas y peligrosas
|
Broad subject area(s) |
|
Navegación por categoria(s) |
Heterocyclic compounds Diseases of the nervous system
|