| ID (ISN) del documento | 21834 |
| Número CIS |
74-2069 |
| ISSN - Título de la serie |
0041-008X - Toxicology and Applied Pharmacology |
| Año |
1974 |
| Número de serie |
|
| Autor(es) |
Mundy R.L., Hall L.M., Teague R.S. |
| Título |
Pyrazole as an antidote for ethylene glycol poisoning. |
| Información bibliográfica |
May 1974, Vol.28, No.2, p.320-322. 12 ref. |
| Resumen |
Pyrazole, a potent alcohol dehydrogenase inhibitor, given intraperitoneally to mice in a single dose of 300mg/kg, increased significantly the LD50 of orally-administered ethylene glycol. It appears to act like ethanol in preventing conversion of glycol to more toxic metabolites. Although pyrazole is a toxic chemical and may cause damage in several organs in experimental animals, the compound has been used in experimental studies in man; its use on a one-time basis in life-threatening poisoning might be an acceptable risk. |
| Descriptores (primarios) |
etilenglicol; pirazolo; tratamiento por antídotos |
| Descriptores (secundarios) |
investigaciones en el animal; metabolización |
| Tipo de documento |
- |
| Tema(s) |
Medicina del trabajo, higiene, primeros auxilios
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Alcohols
Heterocyclic compounds
Glycols
|
