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Base de datos CISDOC

ID (ISN) del documento18765
Número CIS 73-1341
ISSN - Título de la serie 0003-9896 - Archives of Environmental Health
Año 1972
Número de serie
Autor(es) Bingham E.
Título Responses of alveolar macrophages - I. Inhalation of lead and nickel
Información bibliográfica Dec. 1972, Vol.25, No.6, p.406-414. Illus. 13 ref.
Resumen Rats were subjected for one or several weeks to the inhalation of soluble and insoluble aerosols of lead and nickel (PbCl2, Pb2O3, NiCl2, NiO) at concentrations near or below the occupational TLVs. The number of alveolar macrophages was significantly increased after exposure to NiO, significantly decreased with Pb2O3 and not significantly altered with PbCl2 and NiCl2. The histopathological examination (light microscopy) of the lungs revealed changes after the inhalation of both nickel compounds. The experimental results suggest that the level of the current TLV for nickel (1000µg/m3) should be re-evaluated, as it may be too high.
Descriptores (primarios) valores umbrales; níquel y sus compuestos; efectos biológicos; inhalación; plomo y sus compuestos
Descriptores (secundarios) macrófagos; níquel; plomo; depósito en los pulmones; riesgos para la salud; investigaciones en el animal; histopatología; microscopía óptica; pruebas por inhalación; enfermedades respiratorias
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Occupational exposure limits
Nickel and compounds
Lead and compounds
Inorganic substances