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Base de datos CISDOC

ID (ISN) del documento112303
Número CIS 12-0225
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 2011
Número de serie
Autor(es) Gaudin R., Marsan P., Ndaw S., Robert A., Ducos P.
Título Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: A field study
Información bibliográfica June 2011, Vol.84, No.5, p.523-531. Illus. 54 ref.
Acceso Internet Biological_monitoring_of_exposure_[INTERNET_FREE_ACCESS] [en inglés]
Resumen The aim of this study was to assess workers' exposure to di(2-ethylhexyl) phthalate (DEHP) in the flexible-PVC industry in France by means of biological monitoring. Over five days of pre-and post-shift sampling, three urinary metabolites of DEHP, mono (2-ethylhexyl) phthalate (MEHP), mono (5-carboxy-2-ethylpentyl) phthalate (5cx-MEPP) and 2-ethylhexanoic acid (2-EHA) were quantified in 62 workers and 29 controls from six factories. Analyses were performed by high-performance liquid chromatography with tandem mass spectrometry after on-line extraction. There is clear evidence of occupational exposure of workers in these factories. Values of 250 and 500 ¿g/l (100 and 280 ¿/g creatinine) for MEHP and 5cx-MEPP, respectively, are proposed as guidance values which should prevent high exposures in the flexible-PVC industry, particularly in factories where DEHP compounds or plastisols are employed.
Descriptores (primarios) ftalato de bis(etilhexilo); cloruro de polivinilo; plastificantes; tests de exposición; transformación de materias plásticas
Descriptores (secundarios) Francia; metabolitos urinarios; dosificación en la orina; valoración de la exposición; valores umbrales
Tipo de documento D - Artículos periódicos
Tema(s) Química, hidrocarburos,plásticos, caucho
Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Exposure evaluation
Phthalates
Chemical industry