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Base de datos CISDOC

ID (ISN) del documento112276
Número CIS 12-0031
ISBN(s) 978-3-7776-1476-2
Año 2006
Número de serie BUA Report 253
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA)
Título 3,7-Dimethyloctane-3-ol
Información bibliográfica Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiv, 53p. Bibl.ref. Price: EUR 47.00.
Acceso Internet BUA_Report_253_Summary_[INTERNET_FREE_ACCESS] [en inglés]
BUA_Report_253_[BUY_THIS_DOCUMENT] [en inglés]
Resumen Conclusions of this criteria document which reflects the state of knowledge as of September 2004: 3,7-dimethyloctane-3-ol is of low acute toxicity. Eight-hour exposure to an atmosphere enriched with 3,7-dimethyloctane-3-ol does not cause symptoms of poisoning in rats. The oral and dermal LD50 in rats is higher than 200 mg/kg. Symptoms of poisoning after oral uptake are dyspnoea, apathy, lateral position, staggering, atony, narcotic condition with an absence of pain and corneal reflexes, a spastic gait, diarrhoea, salivation and lacrimation. In rabbits, 3,7-dimethyloctane-3-ol causes slight-to-moderate irritation to the skin and moderate irritation to the eye. In the maximization test in humans, a 4 % solution does not cause irritation or sensitization after 48-hour occlusive application. 3,7-Dimethyloctane-3-ol is not mutagenic in the mutagenicity test with various Salmonella typhimurium strains and V79 cells. It does not cause chromosome aberrations in V79 cells. Studies on the carcinogenic potential of 3,7-dimethyloctane-3-ol are not available. Other findings are discussed.
Descriptores (primarios) Alemania; alcoholes alifáticos; toxicología; ecotoxicología
Descriptores (secundarios) irritación; investigaciones en el animal; revisión bibliográfica; documentación de base
Tipo de documento B - Fichas de información de seguridad química
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Alcohols