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Base de datos CISDOC
| ID (ISN) del documento | 112276 |
| Número CIS |
12-0031 |
| ISBN(s) |
978-3-7776-1476-2 |
| Año |
2006 |
| Número de serie |
BUA Report 253
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| Autor(es) |
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA) |
| Título |
3,7-Dimethyloctane-3-ol |
| Información bibliográfica |
Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiv, 53p. Bibl.ref. Price: EUR 47.00. |
| Acceso Internet |
BUA_Report_253_Summary_[INTERNET_FREE_ACCESS] [en inglés]
BUA_Report_253_[BUY_THIS_DOCUMENT] [en inglés]
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| Resumen |
Conclusions of this criteria document which reflects the state of knowledge as of September 2004: 3,7-dimethyloctane-3-ol is of low acute toxicity. Eight-hour exposure to an atmosphere enriched with 3,7-dimethyloctane-3-ol does not cause symptoms of poisoning in rats. The oral and dermal LD50 in rats is higher than 200 mg/kg. Symptoms of poisoning after oral uptake are dyspnoea, apathy, lateral position, staggering, atony, narcotic condition with an absence of pain and corneal reflexes, a spastic gait, diarrhoea, salivation and lacrimation. In rabbits, 3,7-dimethyloctane-3-ol causes slight-to-moderate irritation to the skin and moderate irritation to the eye. In the maximization test in humans, a 4 % solution does not cause irritation or sensitization after 48-hour occlusive application. 3,7-Dimethyloctane-3-ol is not mutagenic in the mutagenicity test with various Salmonella typhimurium strains and V79 cells. It does not cause chromosome aberrations in V79 cells. Studies on the carcinogenic potential of 3,7-dimethyloctane-3-ol are not available. Other findings are discussed. |
| Descriptores (primarios) |
Alemania; alcoholes alifáticos; toxicología; ecotoxicología |
| Descriptores (secundarios) |
irritación; investigaciones en el animal; revisión bibliográfica; documentación de base |
| Tipo de documento |
B - Fichas de información de seguridad química |
| Tema(s) |
Sustancias tóxicas y peligrosas
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| Broad subject area(s) |
Riesgos químicos
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| Navegación por categoria(s) |
Alcohols
Toxicology
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