|ID (ISN) del documento||111940|
|ISSN - Título de la serie
||1351-0711 - Occupational and Environmental Medicine
|Número de serie
||Labrèche F., Goldberg M.S., Valois M.F., Nadon L.
||Postmenopausal breast cancer and occupational exposures
||Apr. 2010, Vol.67, No.4. p.263-269. 47 ref.
||The objective of this study was to determine whether exposures in the workplace to organic solvents and to other agents, such as polycyclic aromatic hydrocarbons, are associated with increased risks of developing postmenopausal breast cancer. It was conducted in the form of a case-control study in Montreal, Canada. Cases comprised 556 women, aged 50-75 years, with incident malignant breast cancer, while controls were 613 women with other cancers, frequency-matched for age and time of diagnosis. An expert team of chemists and industrial hygienists translated their job histories into exposure to about 300 agents. Increased odds ratios (ORs) were found for each 10-year increment in duration of exposure, before age 36 years (OR(<36)), to acrylic fibres (OR(<36) 7.69) and to nylon fibres (OR(<36) 1.99). For oestrogen-positive and progesterone-negative tumours, the OR doubled or more for each 10-year increase in exposure to mono-aromatic hydrocarbons, and to acrylic and rayon fibres. The OR(<36) also doubled for exposure to organic solvents that metabolise into reactive oxygen species, and to acrylic fibres. A threefold increase was found for oestrogen- and progesterone-positive tumours, with exposure to polycyclic aromatic hydrocarbons from petroleum sources. Findings are consistent with the hypothesis that breast tissue is more sensitive to adverse effects if exposure occurs when breast cells are still proliferating.
||Quebec; cáncer de mama; menopausia; riesgos químicos; factores de riesgo
||Canadá; hidrocarburos aromáticos; poliamidas; poliacrilonitrilo; disolvente; valoración de la exposición; estudio del caso y testigo; industria de las fibras sintéticas
|Tipo de documento
||D - Artículos periódicos
Sustancias tóxicas y peligrosas
|Broad subject area(s)
||Medicina del trabajo, epidemiología
Industrias y ocupaciones
|Navegación por categoria(s)
||Cancer and carcinogens