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ID (ISN) del documento111789
Número CIS 11-0371
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 2011
Número de serie
Autor(es) Fedeli U., Mastrangelo G.
Título Vinyl chloride industry in the courtroom and corporate influences on the scientific literature
Información bibliográfica 2011, Vol.54, p.470-473. 27 ref.
Resumen Pressure from the vinyl chloride (VC) industry on researchers involved in industry-sponsored studies and on regulatory agencies has been documented since the 1970s. This commentary describes the influence of a lawsuit pursued by workers of an Italian VC plant on the recent scientific debate on VC exposure and risk of hepatocellular carcinoma (HCC). Original studies carried out by consultants of the public prosecutors and by independent researchers supported the above association. VC-industry consultants published two reviews during the lawsuit, claiming that liver angiosarcoma was the only VC-related cancer. The judges concluded that the evidence of the association between HCC and VC was still not convincing. After the trial, the risk of HCC was confirmed by a re-assessment of VC carcinogenicity from the International Agency for Research on Cancer, but other subsequent industry-funded reviews criticized the new evidence. Industry-funded authors cited each other, and rarely disclosed conflicts of interest. Based on a network of collaborating researchers, industrial interests can shape the literature enhancing the background noise surrounding the scientific evidence.
Descriptores (primarios) Italia; cloruro de vinilo; cáncer de hígado; factores de riesgo
Descriptores (secundarios) grandes empresas; angiosarcoma; deontología; difusión de la información; aspectos legales; jurisprudencia
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Navegación por categoria(s) Cancer and carcinogens
Liver diseases