ILO Home
Volver a la página de entrada
Site map | Contact us English | Français

Base de datos CISDOC

ID (ISN) del documento111782
Número CIS 11-0367
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 2011
Número de serie
Autor(es) Friesen M.C., Costello S., Thurston S.W., Eisen E.A.
Título Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers
Información bibliográfica 2011, Vol.54, p.450-460. Illus. 42 ref.
Resumen The various types of metalworking fluids (MWFs) have overlapping components. This study derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides and nitrosamines to account for this overlap and examined their relations with cancer incidence. An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios for each cancer and cumulative exposures were estimated. For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH. Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. These findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies.
Descriptores (primarios) líquidos de corte; cáncer; industria del automóvil
Descriptores (secundarios) hidrocarburos aromáticos; hidrocarburos policíclicos; nitrosaminas; biocidas; valoración de la exposición; estudio de cohorte; tasas de frecuencia
Tipo de documento D - Artículos periódicos
Tema(s) Metalurgia, trabajo de los metales
Sustancias tóxicas y peligrosas
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Navegación por categoria(s) Cancer and carcinogens
Aromatic hydrocarbons
Polycyclic hydrocarbons
Motor vehicle manufacturing industry