| ID (ISN) del documento | 110857 |
| Número CIS |
10-0437 |
| ISSN - Título de la serie |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Año |
2010 |
| Número de serie |
|
| Autor(es) |
Costa G., Haus E., Stevens R. |
| Título |
Shift work and cancer - Considerations on rationale, mechanisms, and epidemiology |
| Información bibliográfica |
Mar. 2010, Vol.36, No.2, p.163-179. 185 ref. |
| Acceso Internet |
Shift_work_and_cancer.pdf [en inglés]
|
| Resumen |
This literature survey reviews the association between shift work and cancer. The mechanisms by which circadian disruption may cause malignant tumours are complex and multifactorial. The multilevel endocrine changes caused by circadian disruption with melatonin suppression through light at night lead to the oncogenic targeting of the endocrine-responsive breast in women and possibly the prostate in men. Repeated phase shifting with internal desynchronization may lead to defects in the regulation of the circadian cell cycle, thus favouring uncontrolled growth. Sleep deprivation leads to the suppression of immune surveillance that may permit the onset and growth of malignant clones. However, many epidemiological studies published lack methodological rigour and consequently do not allow for the proper assessment of the risk connected with circadian disruption. |
| Descriptores (primarios) |
trabajo por turnos; cáncer; factores de riesgo |
| Descriptores (secundarios) |
cáncer de mama; cáncer de próstata; ritmo circadiano; privacion de sueno; diferencias por el sexo; revisión bibliográfica |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Patología profesional
|
| Broad subject area(s) |
Fisiología, ergonomía
|
| Navegación por categoria(s) |
Cancer and carcinogens
Hours of work
|
