| ID (ISN) del documento | 110625 |
| Número CIS |
10-0247 |
| ISSN - Título de la serie |
0340-0131 - International Archives of Occupational and Environmental Health |
| Año |
2008 |
| Número de serie |
|
| Autor(es) |
Kawai T., Ukai H., Inoue O., Maejima Y., Fukui Y., Ohashi F., Okamoto S., Takada S., Sakurai H., Ikeda M. |
| Título |
Evaluation of biomarkers of occupational exposure to toluene at low levels |
| Información bibliográfica |
Jan. 2008, Vol.81, No.3, p.253-262. Illus. 42 ref. |
| Resumen |
The purpose of this study was to compare various biomarkers of occupational exposure to toluene (Tol) at low levels. The focus was placed on the comparison of un-metabolized toluene in urine (Tol-U) and peripheral blood (Tol-B) with hippuric acid in urine (HA-U). The study was conducted at 16 workplaces with the participation of male solvent-exposed workers. Urine and peripheral blood samples were collected at the end of the shifts. Time-weighted average exposures were monitored by diffusive sampling for toluene and other four solvents. Blood samples were subjected to the analyses for Tol-B, whereas urine samples were analyzed for HA-U and Tol-U. Solvent exposures were low. The correlation analyses of the biomarkers in urine and blood with Tol exposure showed that Tol-U and Tol-B were more closely related than HA-U. Results of receiver operator characteristic analyses were in agreement with the correlation analysis results. Tol in the end-of-shift spot urine sample appears to be the marker of choice for biological monitoring of occupational exposure to Tol at low levels. |
| Descriptores (primarios) |
tolueno; tests de exposición; fiabilidad |
| Descriptores (secundarios) |
Japón; ácido hipúrico; dosificación en el aire; dosificación en la sangre; dosificación en la orina; valoración de la exposición; valoración estadística; trabajadores masculinos; descripción del procedimiento |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Air pollution
Biological monitoring
Printing, photography and photocopying industry
|
