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ID (ISN) del documento110292
Número CIS 09-1335
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 2009
Número de serie
Autor(es) González-Yebra A.L., Kornhauser C., Barbosa-Sabanero G., Pérez-Luque E.L., Wrobel K.
Título Exposure to organic solvents and cytogenetic damage in exfoliated cells of the buccal mucosa from shoe workers
Información bibliográfica Feb. 2009, Vol.82, No.3, p.373-380. Illus. 34 ref.
Resumen The objective of this study was to evaluate the genotoxicity of solvents used in shoemaking. Thirty-four exposed Mexican shoe workers and 34 unexposed control subjects, paired by age and sex, were compared. Occupational exposure was determined by personal monitoring followed by gas chromatography. Exfoliated buccal cells of each subject were used to determine the incidence of micronuclei and other nuclear abnormalities. Solvents detected were acetone, ethyl acetate, butanone and toluene. The incidence of nuclear abnormalities was significantly higher in the exposed group. A positive relationship was found between the incidence of micronuclei and workplace toluene concentrations. The micronucleus test is proposed as a low cost biomarker of genotoxicity.
Descriptores (primarios) México; disolventes orgánicos; industria del calzado; factores de riesgo; efectos genéticos
Descriptores (secundarios) anomalías genéticas; muestreo individual; acetona; butanona; cromatografía en fase gaseosa; tolueno; valoración de la exposición; relación dosis-respuesta; acetato de etilo
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaMéxico
Tema(s) Cueros y pieles, calzados
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Footwear, leather and fur industry
Genetic factors in reaction to exposures