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Base de datos CISDOC

ID (ISN) del documento110092
Número CIS 09-1111
ISSN - Título de la serie 1076-2752 - Journal of Occupational and Environmental Medicine
Año 2008
Número de serie
Autor(es) Rajan P., Kelsey K.T., Schwartz J.D., Bellinger D.C., Weuve J., Spiro A., Sparrow D., Smith T.J., Nie H., Weisskopf M.G., Hu H., Wright R.O.
Título Interaction of the δ-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: The VA normative ageing study
Información bibliográfica Sep 2008, Vol.50, No.9, p.1053-1061. 36 ref.
Resumen This study evaluated the modifying influence of a δ-aminolevulinic acid dehydratase (ALAD) gene polymorphism on the relation between lead burden and cognition among older men. Information on ALAD genotype, lead measurements, potential confounders and cognitive testing was collected from 982 veterans. Data were analyzed using multiple linear regression models. With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers. However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests.
Descriptores (primarios) rendimiento cognitivo; plomo y sus compuestos; efectos genéticos; envejecimiento; ALAD
Descriptores (secundarios) trabajadores de edad; enzimas; dosificación en los huesos; valoración estadística; fuerzas armadas
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Older workers
Lead and compounds
Inorganic substances
Genetic factors in reaction to exposures