| ID (ISN) del documento | 110089 |
| Número CIS |
09-1129 |
| ISSN - Título de la serie |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Año |
2008 |
| Número de serie |
|
| Autor(es) |
Jönsson L.S., Littorin M., Axmon A., Jönsson B.A.G., Broberg K. |
| Título |
Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden |
| Información bibliográfica |
Sep 2008, Vol.50, No.9, p.1006-1012. 43 ref. |
| Resumen |
The objective of this study was to evaluate the risk of impaired lung function among Swedish rubber workers. Included in the study were 159 rubber exposed and 118 unexposed controls. Urinary levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) were assessed by liquid chromatography coupled with mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and conventional polymerase chain reaction. There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. Implications of these findings are discussed. |
| Descriptores (primarios) |
industria del caucho; Suecia; ácido tio-2 tiazolidinacarboxilica-4; afectación respiratoria; efectos genéticos; factores de riesgo; función pulmonar |
| Descriptores (secundarios) |
espectrometría de masa; sulfuro de carbono; glutatión; glutation-transferasa; estudio del caso y testigo; cromatografía en fase liquida a alta presión; relación dosis-respuesta; toma de muestras y análisis; tests de exposición; dosificación en la orina; agentes vulcanizantes; espirometría |
| Tipo de documento |
D - Artículos periódicos |
| País / Estado o Provincia | Suecia |
| Tema(s) |
Química, hidrocarburos,plásticos, caucho
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Rubber industry
Heterocyclic compounds
Genetic factors in reaction to exposures
Diseases of the respiratory system (except for pneumoconiosis & similar)
Antifertility and prenatal effects
|
