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ID (ISN) del documento109734
Número CIS 09-563
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 2008
Número de serie
Autor(es) Ates I., Suzen H.S., Yucesoy B., Tekin I.O., Karakaya A.
Título Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
Información bibliográfica Oct. 2008, Vol.51, No.10, p.741-747. 49 ref.
Resumen To determine the cytokine gene profiles of Turkish coal miners, a genotyping analysis was performed to investigate the polymorphisms pro-inflammatory (TNFA, IL1A, IL1B, and IL6) and anti-inflammatory cytokines (IL-1RN and TGFB1) related to coal workers' pneumoconiosis (CWP). An additional goal was to observe whether these cytokine gene polymorphisms influence the development risk and severity of CWP. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Findings suggest that the TNFA (-238) variant may be a risk factor in both the development and severity of CWP, while the TNFA (-308) variant seems to be important only in disease severity. On the other hand, IL6 variant may have a protective effect on the development and disease severity.
Descriptores (primarios) Turquía; efectos genéticos; neumoconiosis de los hulleros; mineria del carbón; factores de riesgo
Descriptores (secundarios) interleucinas; tasas de gravedad; inflamaciones; ADN
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaTurquía
Tema(s) Minas y canteras
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Antifertility and prenatal effects
Mining and quarrying
Genetic factors in reaction to exposures
Neumoconiosis