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ID (ISN) del documento109305
Número CIS 09-419
ISSN - Título de la serie 1351-0711 - Occupational and Environmental Medicine
Año 2007
Número de serie
Autor(es) Wang H., Chen W., Zheng H., Guo L., Liang H., Yang X., Bai Y., Sun J., Su Y., Chen Y., Yuan J., Bi Y., Wei Q., Wu T.
Título Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers
Información bibliográfica Nov. 2007, Vol.64, No.11, p.753-758. Illus. 40 ref.
Resumen Coke oven emissions (COE) containing polycyclic aromatic hydrocarbons can induce both benzo[a]pyrene-r-7, t-8, t-9,c-10-tetrahydrotetrol-albumin (BPDE-Alb) adducts and DNA damage. However, the relation between these biomarkers for early biological effects is not well documented in coke oven workers. In this study, 207 male workers exposed to COE and 102 controls not exposed to COE were recruited in the same steel plant in northern China. BPDE-Alb adduct concentrations in plasma was measured by reverse-phase high performance liquid chromatography and DNA damage in peripheral blood lymphocytes by alkaline comet assay. Multivariate logistic regression analysis revealed significant correlations between the concentrations of BPDE-Alb adduct and Olive TM levels in exposed but not in control group. The results suggest that occupational exposure to COE may induce both BPDE-Alb adducts and DNA damage in the lymphocytes of coke oven workers and that these two markers are useful for monitoring exposure to COE in the workplace.
Descriptores (primarios) linfocitos; hidrocarburos aromáticos; efectos genéticos; hidrocarburos policíclicos; hornos de coque
Descriptores (secundarios) China; cromatografía de alta resolución; dosificación en la sangre; estudio del caso y testigo; valoración estadística; ADN
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaChina
Tema(s) Metalurgia, trabajo de los metales
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Polycyclic hydrocarbons
Aromatic hydrocarbons
Genetic factors in reaction to exposures