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ID (ISN) del documento108994
Número CIS 08-1300
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 2008
Número de serie
Autor(es) Ates I., Suzen H.S., Yucesoy B., Tekin I.O., Karakaya A.
Título Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
Información bibliográfica Oct. 2008, Vol.51, No.10, p.741-747. 49 ref.
Resumen Cytokines are believed to play a key role in inflammatory mechanisms that result in several diseases such as coal workers' pneumoconiosis (CWP). To determine the cytokine gene profiles of Turkish coal miners, a genotyping analysis was performed to investigate the polymorphisms of CWP-related pro-inflammatory and anti-inflammatory cytokines. Genotyping was carried out by the polymerase chain reaction technique, coupled with fragment length polymorphism restriction. It was found that the TNFA (-238) variant was a risk factor in both the development and severity of CWP, while the TNFA (-308) variant was important only in disease severity. On the other hand, IL6 variant may have a protective effect on both development and severity.
Descriptores (primarios) Turquía; efectos genéticos; neumoconiosis de los hulleros; mineria del carbón; factores de riesgo
Descriptores (secundarios) interleucinas; tasas de gravedad; inflamaciones; ADN
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaTurquía
Tema(s) Minas y canteras
Broad subject area(s) Medicina del trabajo, epidemiología
Industrias y ocupaciones
Navegación por categoria(s) Mining and quarrying
Genetic factors in reaction to exposures
Neumoconiosis
Antifertility and prenatal effects