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ID (ISN) del documento108859
Número CIS 08-1379
ISSN - Título de la serie 0339-6517 - Documents pour le médecin du travail
Año 2008
Número de serie DMT 114TF170
Autor(es) Jacob S., Héry M., Stengel B.
Título Exposure to organic solvents - Risk of evolution of chronic renal diseases towards terminal renal insufficiency
Título original Exposition aux solvants organiques - Risque de progression des maladies rénales chroniques vers l'insuffisance rénale terminale [en francés]
Información bibliográfica June 2008, No.114, p.233-241. Illus. 33 ref.
Acceso Internet$File/TF170.pdf [en francés]
08-1379.pdf [en francés]
Resumen This article describes a retrospective cohort study involving 338 patients suffering from glomerular nephropathies for which biopsies were performed between 1994 and 2001, and who were followed up until 2004. Their exposures to solvents were evaluated by industrial hygienists on the basis of interview data. Terminal renal insufficiency (TRI) was defined either as the patient requiring dialysis or a glomerular filtration rate of less than 15mL/min per 1.73m2. The relative risks of TRI associated with solvents were estimated using Cox regression models. It was found that high solvent exposure levels were associated with twofold to fourfold higher TRI risks. Products or chemicals giving rise to the greatest risks were printing inks, fuels, toluene, xylene, petroleum products and acetone. The most exposed workers were mechanics and fitters, plumbers and welders. These findings highlight the importance of screening for glomerular diseases and increased medical supervision of workers exposed to solvents in occupational settings.
Descriptores (primarios) enfermedades crónicas; factores de riesgo; disolventes orgánicos; enfermedades del rinon
Descriptores (secundarios) productos del petróleo; diálisis; acetona; tolueno; relación entre la profesión y la enfermedad; tintas tipográficas; insuficiencia renal; combustibles; diagnostico; xileno; valoración del riesgo; valoración de la exposición; estudio de cohorte; biopsia; relación trabajo-exposición; valoración estadística; vigilancia médica; Francia
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaFrancia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Medicina del trabajo, epidemiología
Navegación por categoria(s) Diseases of the kidney and the urinary system