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ID (ISN) del documento108385
Número CIS 08-905
ISBN(s) 978-3-86509-617-3
Año 2006
Número de serie Fb 1085
Autor(es) Oltmanns J., Schneider K.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Título Examination of the limit dose for the classification of substances as toxic for reproduction
Título original Überprüfung der Grenzdosis zur Einstufung reproduktionstoxischer Stoffe [en alemán]
Información bibliográfica Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2006. 65p. Illus. 70 ref. Price: EUR 10.50.
Acceso Internet 08-0905.pdf [en alemán]
Resumen A dose of 1000mg/kg body weight/day is generally cited in EU directives and OECD guidelines as a maximum dose for studies on reproductive toxicity. This project investigated whether this limit remained valid in cases of high levels of workplace exposure. To this end, published exposure data together with data from the MEGA database of the German Mutual Occupational Accident Insurance Association were evaluated. It was noted that exposures to ambient concentrations of volatile substances were in the 500 to 2000mg/m3 range (time weighted averages), while the inhalation exposures to aerosols and skin exposures were low. By using the appropriate extrapolation factors, the corresponding doses were calculated for animal experiments. For volatile substances, these doses were found to be considerably higher than 1000mg/kg/day. The analysis of the results together with other findings shows that the general concept of a limit dose of 1000mg/kg/day for the classification of substances that are toxic for reproduction is not suited to all chemicals.
Descriptores (primarios) valores umbrales; substancias tóxicas; Alemania; efectos esterilizantes
Descriptores (secundarios) informe; inhalación; absorción cutánea; clasificación; fiabilidad; valoración de la toxicidad; extrapolación del animal al hombre; substancias volátiles
Tipo de documento E - Libros, informes, actas
País / Estado o ProvinciaAlemania
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Occupational exposure limits