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ID (ISN) del documento108223
Número CIS 08-667
ISSN - Título de la serie 1877-7856 - Encyclopédie médico-chirurgicale
Año 2007
Número de serie Fascicule 16002 F 10, 1-2007
Autor(es) Flesch F., Tournoud C., Thaon I., Benhassine E.
Título Iron poisoning
Título original Intoxications par le fer [en francés]
Información bibliográfica Toxicologie-Pathologie professionnelle, 1st Quarter 2007, No.154, 6p. 53 ref.
Resumen Most acute intoxications caused by iron are the result of ferrous salt ingestion, either accidentally in children or more rarely in suicidal attempts among adults. The main toxic mechanism of iron is related to its capacity to induce the formation of free radicals, followed by lipid peroxidation. Classically, five clinical phases have been identified: gastrointestinal toxicity; transitory relative stability; systemic toxicity with shock, metabolic acidosis and coma; hepatotoxicity with coagulopathy; gastrointestinal scarring. Therapy includes supportive care, whole bowel irrigation and the use of deferoxamine, a specific iron chelator. Activated charcoal is ineffective. Chronic exposure to iron occurs primarily in occupational settings and causes pneumoconiosis following the inhalation of dust and iron oxides. Ocular siderosis is a chronic disease that may lead to a vision loss. It occurs when a particle containing iron penetrates in the eye.
Descriptores (primarios) envenenamiento; hierro y sus compuestos; hierro; factores de riesgo; Francia; toxicología; enfermedades profesionales
Descriptores (secundarios) revisión bibliográfica; ninos; envenenamiento agudo; deferoxamina; ingestión; neumoconiosis; nota informativa; siderosis; suicidio; intoxicaciones crónicas; tratamiento médico; enciclopedia; enfermedades gastrointestinales
Tipo de documento F - Notas informativas, directrices prácticas, normas
País / Estado o ProvinciaFrancia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Iron and compounds
Inorganic substances