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Base de datos CISDOC

ID (ISN) del documento108030
Número CIS 08-643
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 2007
Número de serie
Autor(es) Stewart W.F., Schwartz B.S.
Título Effects of lead on the adult brain: A 15-year exploration
Información bibliográfica 2007, Vol.50, p.729-739. Illus. 46 ref.
Acceso Internet 08-0643.pdf [en inglés]
Resumen Three independent longitudinal studies were initiated to determine whether cumulative lead exposure was associated with persistent or progressive neurotoxic effects. The studies include former United States organolead manufacturing workers, current and former inorganic lead workers in Korea and Baltimore residents with environmental lead exposure. In each of these studies, blood lead was measured, as well as tibia and patella lead by X-ray fluorescence. Higher tibia lead was consistently associated with poorer measures of cognitive function. Longitudinal analysis of the Korean and organolead cohort indicate that the effect of lead is persistent. Moreover, MRI data on organolead workers indicates a possible progressive effect. Higher tibia lead was associated with lower brain volume. Findings suggest that a significant proportion of what is considered to be normal age-related cognitive decline may, in fact, be due to past exposure to neurotoxicants such as lead.
Descriptores (primarios) efectos neurotóxicos; Estados Unidos; exposición de larga duración; plomo; compuestos organoplúmbicos; plomo y sus compuestos
Descriptores (secundarios) Corea, República de; rendimiento cognitivo; fluorescencia de rayos x; observación de larga duración; imágenes obtenidas por resonancia magnética; valoración estadística; propiedades acumulativas; dosificación en la sangre; dosificación en los huesos; diferencias por la edad
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Diseases of the nervous system
Lead and compounds
Inorganic substances