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CISDOC database

Document ID (ISN)78714
CIS number 02-846
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2001
Convention or series no.
Author(s) Cocco P., Rice C.H., Chen J.Q., McCawley M.A., McLaughlin J.K., Dosemeci M.
Title Lung cancer risk, silica exposure, and silicosis in Chinese mines and pottery factories: The modifying role of other workplace lung carcinogens
Bibliographic information Dec. 2001, Vol.40, No.6, p.674-682. 32 ref.
Abstract To explore whether exposure to other lung carcinogens, or clinical features of silicosis, modify or confound the association between silica and lung cancer, data from a nested case-control study conducted in the late 1980s in 29 Chinese mines and potteries were used. The were 316 lung cancer cases and 1,356 controls, matched by decade of birth and facility type. Pooling the 29 work sites, the study showed a moderate association between lung cancer risk and silica exposure. Risk did not vary after excluding subjects with silicosis or adjusting the risk estimates by radiological staging of silicosis. The results suggest that numerous occupational and non-occupational risk factors interact in a complex fashion to modify lung cancer risk.
Descriptors (primary) carcinogens; silica; lung cancer; mining industry; confounding factors; risk factors; pottery
Descriptors (secondary) China; non-occupational factors; case-control study; silicosis; radiological diagnosis
Document type D - Periodical articles
Country / State or ProvinceChina; Italy; USA
Subject(s) Materials, glass and ceramics
Broad subject area(s) Chemical safety
Browse category(ies) Mining and quarrying
Diseases of the respiratory system (except for pneumoconiosis & similar)