|Document ID (ISN)||78539|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Luo J.C., Kuo H.W., Cheng T.J., Chang M.J.W.
||Abnormal liver function associated with occupational exposure to dimethylformamide and hepatitis B virus
||May 2001, Vol.43, No.5, p.474-482. 29 ref.
||02-0815.pdf [in English]
||N,N-Dimethylformamide (DMF) has excellent solvent properties and is used intensively in the production of synthetic leather and resins. It has caused hepatoxicity in human and animal studies. Hepatitis B virus (HBV) and hepatitis C virus infections are reported to be the major causes of chronic liver diseases (including liver cirrhosis and liver cancer) in Taiwan. This study examined the dose-response relationship of the observed abnormal liver function among the DMF-exposed workers and the interactions among DMF, other chemical exposures, HBV infection, and potential confounders on liver abnormalities. It was observed that a significant dose-response relationship existed between liver function abnormalities and DMF exposure among workers in Taiwan, and that HBV carrier status or increased BMI had synergistic effects with DMF exposure in causing liver abnormalities (abnormal liver function tests and clinical chronic liver diseases).
||hepatotoxic effects; infectious hepatitis; dimethylformamide
||dose-response relationship; Taiwan (China)
||D - Periodical articles
|Country / State or Province||Taiwan (China)|
|Broad subject area(s)
Bacterial and parasitic diseases
Viral diseases (other than aids)