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Document ID (ISN)78449
CIS number 02-809
ISSN - Serial title 1232-1087 - International Journal of Occupational Medicine and Environmental Health
Year 2001
Convention or series no.
Author(s) Sallmén M.
Title Exposure to lead and male fertility
Bibliographic information July-Sep. 2001, Vol.14, No.3, p.219-222. 20 ref.
Internet access 02-0809.pdf [in English]
Abstract This literature review summarizes the epidemiological evidence for the effects of inorganic lead on male fertility. Blood lead measurements were applied to exposure assessment in all the studies. The results of the studies on fertility rates are consistent in showing an association between lead and reduced fertility. Also, there seems to be a tendency towards stronger association at older age with increasing duration of exposure. The studies conducted suggest that male exposure to lead may be associated with delayed conception. There are a number of mechanisms by which exposure to lead may reduce male fertility. On the basis of animal studies, alterations in sperm chromatin stability or epigenetic effects may be the most probable mechanisms involved at low exposure level.
Descriptors (primary) antifertility effects; lead; male workers
Descriptors (secondary) literature survey; spermatogenic disturbances; exposure evaluation; determination in blood; genetic effects; age-linked differences; length of exposure; animal experiments
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Lead and compounds