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Document ID (ISN)78389
CIS number 02-806
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2002
Convention or series no.
Author(s) Wild P., Leodolter K., Réfrégier M., Schmidt H., Zidek T., Haidinger G.
Title A cohort mortality study and nested case-control study of French and Austrian talc workers
Bibliographic information Feb. 2002, Vol.59, No.2, p.98-105. 29 ref.
Abstract The mortality of two historical cohorts comprised of male subjects who had worked for at least one year in talc producing companies in France and Austria was compared with local death rates. Case-control studies focusing on respiratory diseases were set up to estimate possible dose-response relations with estimated cumulative exposure to talc dust. Mortality from lung cancer was in small excess in both cohorts (France, standardized mortality ratio (SMR) 1.23, 21 cases observed, Austria SMR 1.06, seven cases observed). The case-control study of non-malignant respiratory disease showed an increased mortality in the highest exposure groups (odds ratio (OR) 2.5 for a cumulative exposure ≥800 year.mg/m3) with a significant trend (OR/100 y.mg/m3 1.08) with cumulative exposure to talc. However, no increasing trend could be found in the case-control study of lung cancer. Adjustment for smoking and exposure to quartz had no significant influence on the results.
Descriptors (primary) talc; mortality; quarrying industry; lung cancer; respiratory diseases
Descriptors (secondary) Austria; France; respirable dust; dose-response relationship; case-control study; cohort study; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceAustria; France
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Mining and quarrying
Diseases of the respiratory system (except for pneumoconiosis & similar)