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CISDOC database
Document ID (ISN) | 77286 |
CIS number |
01-1468 |
ISSN - Serial title |
1529-8663 - AIHA Journal |
Year |
2001 |
Convention or series no. |
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Author(s) |
Kezic S., Monster A.C., van de Gevel I.A., Krüse J., Opdam J.J.G., Verberk M.M. |
Title |
Dermal absorption of neat liquid solvents on brief exposures in volunteers |
Bibliographic information |
Jan.-Feb. 2001, Vol.62, No.1, p.12-18. Illus. 35 ref. |
Abstract |
1,1,1-trichloroethane (111TRI), trichloroethylene (TRI), tetrachloroethylene (TETRA), toluene (TOL) and m-xylene (XYL) were applied for 3min on the forearm of six volunteers. Permeation rates were calculated from exhaled air concentrations. TRI, TOL, and 111TRI in three subjects reached maximal permeation rates a few minutes after initiation of exposure. Slower permeation was seen in the other three subjects exposed to 111TRI, and in all subjects exposed to TETRA and XYL, with the time of maximal permeation rates of 15-25min. These differences in permeation may partly be explained by the irritation of the skin observed in subjects showing fast permeation kinetics. The flux into the skin averaged over the exposure period was 56, 430, 69, 223 and 46nmol/cm2/min for 111TRI, TRI, TETRA, TOL, and XYL, respectively. Comparing the dermal uptake with the respiratory uptake at the TLV, all solvents showed substantial skin absorption, although at present only TOL has a skin indication in the ACGIH threshold limit value list. |
Descriptors (primary) |
1,1,1-trichloroethane; trichloroethylene; m-xylene; toluene; skin absorption; tetrachloroethylene |
Descriptors (secondary) |
threshold limit values; solvents; dermatitis; exhalation |
Document type |
D - Periodical articles |
Country / State or Province | Netherlands |
Subject(s) |
Toxic and dangerous substances
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Broad subject area(s) |
Chemical safety
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Browse category(ies) |
Aromatic hydrocarbons Halogenated hydrocarbons
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