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Document ID (ISN)77286
CIS number 01-1468
ISSN - Serial title 1529-8663 - AIHA Journal
Year 2001
Convention or series no.
Author(s) Kezic S., Monster A.C., van de Gevel I.A., Krüse J., Opdam J.J.G., Verberk M.M.
Title Dermal absorption of neat liquid solvents on brief exposures in volunteers
Bibliographic information Jan.-Feb. 2001, Vol.62, No.1, p.12-18. Illus. 35 ref.
Abstract 1,1,1-trichloroethane (111TRI), trichloroethylene (TRI), tetrachloroethylene (TETRA), toluene (TOL) and m-xylene (XYL) were applied for 3min on the forearm of six volunteers. Permeation rates were calculated from exhaled air concentrations. TRI, TOL, and 111TRI in three subjects reached maximal permeation rates a few minutes after initiation of exposure. Slower permeation was seen in the other three subjects exposed to 111TRI, and in all subjects exposed to TETRA and XYL, with the time of maximal permeation rates of 15-25min. These differences in permeation may partly be explained by the irritation of the skin observed in subjects showing fast permeation kinetics. The flux into the skin averaged over the exposure period was 56, 430, 69, 223 and 46nmol/cm2/min for 111TRI, TRI, TETRA, TOL, and XYL, respectively. Comparing the dermal uptake with the respiratory uptake at the TLV, all solvents showed substantial skin absorption, although at present only TOL has a skin indication in the ACGIH threshold limit value list.
Descriptors (primary) 1,1,1-trichloroethane; trichloroethylene; m-xylene; toluene; skin absorption; tetrachloroethylene
Descriptors (secondary) threshold limit values; solvents; dermatitis; exhalation
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic hydrocarbons
Halogenated hydrocarbons