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CISDOC database
| Document ID (ISN) | 77267 |
| CIS number |
01-1466 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2000 |
| Convention or series no. |
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| Author(s) |
Qu Q., Melikian A.A., Li G., Shore R., Chen L., Cohen B., Yin S., Kagan M.R., Li H., Meng M., Jin X., Winnik W., Li Y, Mu R., Li K. |
| Title |
Validation of biomarkers in humans exposed to benzene: Urine metabolites |
| Bibliographic information |
May 2000, Vol.37, No.5, p.522-531. Illus. 26 ref. |
| Abstract |
This study was conducted among workers employed in glue- and shoe-making factories exposed to benzene. The metabolites monitored were S-phenylmercapturic acid (S-PMA), trans,trans-muconic acid (t,t-MA), hydroquinone (HQ), catechol (CAT), 1,2,4-trihydroxybenzene (BT) and phenol. Levels of benzene metabolites (except BT) measured in urine samples collected from exposed workers at the end of the shift were significantly higher than those measured in unexposed subjects. The large increases in urinary metabolites during the shift strongly correlated with benzene exposure. Concentrations of metabolites in urine samples collected from exposed workers before work were also significantly higher than in unexposed subjects. The half-lives of S-PMA, t,t-MA, HQ, CAT and phenol were estimated to be 12.8, 13.7, 12.7, 15.0 and 16.3h, respectively. All metabolites except BT are good markers for benzene exposure at the observed levels; however, S-PMA and t,t-MA are the most sensitive markers for low-level exposure. |
| Descriptors (primary) |
benzene; exposure tests; urinary metabolites |
| Descriptors (secondary) |
S-phenylmercapturic acid; phenol; adhesives; hydroquinone; pyrocatechol; shoe industry; determination in urine; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | China; USA |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Biological monitoring
Aromatic hydrocarbons
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