|Document ID (ISN)||76961|
|ISSN - Serial title
||0003-4878 - Annals of Occupational Hygiene
|Convention or series no.
||Soutar C.A., Robertson A., Miller B.G., Searl A., Bignon J.
||Epidemiological evidence on the carcinogenicity of silica: Factors in scientific judgement
||Jan. 2000, Vol.44, No.1, p.3-14. 69 ref.
||In view of the extended debate and differing opinions on whether crystalline silica is a human carcinogen, a selection of epidemiological reports was reviewed in order to identify the areas of uncertainty and disagreement. Papers which in a recent review were considered to provide the least confounded examinations of an association between silica exposure and cancer risk have been examined together with a study of the mortality of coalminers. It has been found that parts of the evidence were coherent but there were contradictions. On examination, this resolved mostly into differences between types of studies. The three types of epidemiological study included were: exposure-response studies, studies in which incidence of disease in an exposed population is compared with that in a reference population and studies of incidence of disease in subjects on silicosis case-registers. Scientific uncertainties in the evidence (confounders, bias, false assumptions) are discussed.
||silica; carcinogenic effects; lung cancer; epidemiology
||literature survey; cristobalite; European Communities; IARC; classification; occupation disease relation; silicosis; dose-response relationship; quartz
||D - Periodical articles
|Country / State or Province||France; United Kingdom|
||Dust, aerosols and related diseases
|Broad subject area(s)
Diseases of the respiratory system (except for pneumoconiosis & similar)