| Document ID (ISN) | 76602 |
| CIS number |
01-823 |
| ISSN - Serial title |
0003-4878 - Annals of Occupational Hygiene |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Lafontaine M., Payan J.P., Delsaut P., Morele Y. |
| Title |
Polycyclic aromatic hydrocarbon exposure in an artificial shooting target factory: Assessment of 1-hydroxypyrene urinary excretion as a biological indicator of exposure |
| Bibliographic information |
Mar. 2000, Vol.44, No.2, p.89-100. Illus. 27 ref. |
| Abstract |
Five representative workers and two external observers were monitored by personal air and urinary 1-hydroxypyrene (PyOH) sampling for a four-shift working week in an artificial shooting target factory. The targets were made from chalk and petroleum pitch and molded at 190°C. No respiratory protective mask was worn. Atmospheric concentrations of pyrene and benzo(a)pyrene (BaP) ranged from 0.66 to 5.05µg/m3 and 0.037 to 0.270µg/m3 respectively, with a mean pyrene/BaP ratio of approximately 20 and a correlation r = 0.51. Maximum PyOH urinary excretion ranged from 1.84 to 10.9µmol/mol creatinine. The correlation between atmospheric pyrene and urinary PyOH concentrations was poor (r = 0.37). It improved considerably (r = 0.74) if the amount of pyrene inhaled over the shift and the corresponding amount of PyOH excreted were considered. The ratio of urinary excreted PyOH to the pyrene inhaled dose (with assumed retention of 100%), ranged from 0.18 to 0.70 (arithmetic mean =0.34). Although dermal absorption is significant, these results suggests that the respiratory tract is the main absorption route for pyrene. |
| Descriptors (primary) |
aromatic hydrocarbons; exposure tests; polycyclic hydrocarbons; pitch |
| Descriptors (secondary) |
pyrene; inhalation; skin absorption; benzo(a)pyrene; determination in urine; urinary metabolites; 1-hydroxypyrene; respirators; air sampling; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | France |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic hydrocarbons
Biological monitoring
Polycyclic hydrocarbons
|
