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Document ID (ISN)76531
CIS number 01-356
ISBN(s) 90-5549-300-7
Year 1999
Convention or series no. Gezondheidsraad publication 1999/14OSH
Author(s)
Dutch Expert Committee on Occupational Standards (DECOS)
Title Procarbazine hydrochloride - Health-based calculated occupational cancer risk values
Bibliographic information Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 34p. 17 ref.
Abstract Procarbazine hydrochloride is an antineoplastic agent. Additional lifetime cancer risk for procarbazine hydrochloride amounts to 4 x 10-5 for 40 years of occupational exposure to 0.002mg/m3, and 4 x 10-3 for 40 years of occupational exposure to 0.2mg/m3. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers; calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (leucopenia, thrombocytopenia, nausea, vomiting, myelosuppression). Summary in Dutch.
Descriptors (primary) threshold limit values; carcinogens; toxicology; Netherlands; procarbazine hydrochloride; antineoplastic drugs
Descriptors (secondary) toxicity evaluation; criteria document; carcinogenic effects
Document type B - Chemical safety information sheets
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Occupational exposure limits