| Document ID (ISN) | 76153 |
| CIS number |
01-254 |
| ISSN - Serial title |
0944-2502 - Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie |
| Year |
1998 |
| Convention or series no. |
|
| Author(s) |
Doekes G., Houba R., Heederik D. |
| Title |
Enzyme allergy: Standards for airborne exposure in the workplace? |
| Bibliographic information |
Nov. 1998, Vol.48, No.11, p.480-484. Illus. 11 ref. |
| Abstract |
Microbial enzymes are used in the detergent and food industries. They are considered to be a risk factor in the development of occupational asthma. A number of studies have shown that sensitization may occur at concentrations lower than the present Dutch exposure limit of 60ng/m3. Dose-response relationships published for the fungal enzyme alpha-amylase are used to show that this enzyme can induce specific IgE responses and symptoms of allergic respiratory diseases at mean exposure levels of less than 1 to 2ng/m3. Further studies are needed to clarify whether sensitization was due to these mean levels or to repeated short peak exposures of 10 to 100ng/m3 or more which are most likely to occur with some frequency. The enzyme alpha-amylase is used in bakeries to improve the baking quality of the dough. It is derived from the mould Aspergillus oryzae. |
| Descriptors (primary) |
threshold limit values; sensitization; amylase; airborne dust |
| Descriptors (secondary) |
bakery products industry; Netherlands; allergic respiratory disorders; moulds; dose-response relationship; enzymes |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Food, beverage and tobacco industries
|
| Broad subject area(s) |
Biological hazards
|
| Browse category(ies) |
Occupational exposure limits
|
