| Document ID (ISN) | 76074 |
| CIS number |
01-143 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1999 |
| Convention or series no. |
|
| Author(s) |
Robert A., Ducos P., Francin J.M. |
| Title |
Biological monitoring of workers exposed to 4,4'-methylene-bis-(2-orthochloroaniline) (MOCA) |
| Bibliographic information |
July 1999, Vol.72, No.4, p.223-237. Illus. 70 ref. |
| Abstract |
The objectives of the study were to investigate and to validate a new and simple method to determine MOCA in the urine of exposed workers, to identify the best urinary marker of exposure to MOCA and to study its applicability in exposure evaluation in polyurethane resin production plants. Urinary MOCA markers were measured in urine samples collected at the end of the workshifts. Forty workers from four factories were observed for three consecutive days in the same week. "Free" MOCA in non-acid- stabilized urines, "total" MOCA in urines after alkaline hydrolyses, "acid-labile" MOCA in sulfamic or citric acid-protected urines were measured in all urine samples. MOCA liberated by heating the non-acid-stabilized urines ("heat-labile" MOCA) was also measured in 17 urine samples of exposed workers. MOCA measured in sulfamic acid-protected urine samples without hydrolyses provides a more practical and reliable biomarker than "total" MOCA (after hydrolysis) or "free" MOCA. A biological guiding value of 20µg/L expressed as "sulfamic acid-labile" MOCA is proposed. |
| Descriptors (primary) |
methylenebis(2-chloroaniline); urine monitoring; exposure tests; plastics industry |
| Descriptors (secondary) |
polyurethanes; determination in urine; description of technique; high performance chromatography |
| Document type |
D - Periodical articles |
| Country / State or Province | France |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Biological monitoring
Plastics industry
|
