|
|
 |
|
|
CISDOC database
| Document ID (ISN) | 75414 |
| CIS number |
00-1398 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1998 |
| Convention or series no. |
|
| Author(s) |
Blair A., Hartge P., Stewart P.A., McAdams M., Lubin J. |
| Title |
Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: Extended follow up |
| Bibliographic information |
Mar. 1998, Vol.55, No.3, p.161-171. 56 ref. |
| Abstract |
The aim of the study was to extend the follow-up of a cohort of 14,457 aircraft maintenance workers to the end of 1990 to evaluate cancer risks from potential exposure to trichloroethylene and other chemicals. In the combined follow-up period (1952-90), mortality from all causes and all cancer was close to expected. Significant excesses occurred for ischaemic heart disease, asthma and bone cancer, whereas significant deficits occurred for cerebrovascular disease, accidents and cancer of the central nervous system. Workers exposed to trichloroethylene showed non-significant excesses for non-Hodgkin's lymphoma, and cancers of the oesophagus, colon, primary liver, breast, cervix, kidney and bone. None of these cancers showed an exposure-response gradient and relative risks (RRs) among workers exposed to other chemicals but not trichlorethylene often had RRs as large as workers exposed to trichloroethylene. Workers exposed to solvents other than trichloroethylene had slightly increased mortality from asthma, non-Hodgkin's lymphoma, multiple myeloma and breast cancer. These findings do not strongly support a causal link with trichloroethylene because the associations were not significant, not clearly dose-related, and inconsistent between men and women. |
| Descriptors (primary) |
trichloroethylene; mortality; neoplasms; aircraft repair and maintenance; organic solvents |
| Descriptors (secondary) |
lymphoma; myeloma; long-term study; breast cancer; cohort study; asthma |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Halogenated hydrocarbons
Aerospace manufacturing and maintenance industry
|
|
|
|
|
|
