|Document ID (ISN)||75301|
|Convention or series no.
||Gezondheidsraad publication 1999/04OSH
Dutch Expert Committee on Occupational Standards (DECOS)
||Azathioprine - Health-based calculated occupational cancer risk values
||Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 32p. 11 ref.
||Azathioprine is an immunosupressant. Main tumours in human after treatment with azathioprine include non-Hodgkin's lymphoma, squamous cell cancers of the skin, hepatobiliary carcinomas and mesenchymal tumours. Additional lifetime cancer risk for azathioprine amounts to 4 x 10-5 for 40 years of occupational exposure to 0.005mg/m3, and 4 x 10-3 for 40 years of occupational exposure to 0.5mg/m3. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (toxic effect: bone-marrow depression). Summary in Dutch.
||threshold limit values; carcinogens; toxicology; azathioprine; Netherlands
||toxicity evaluation; criteria document; carcinogenic effects
||B - Chemical safety information sheets
|Country / State or Province||Netherlands|
||Toxic and dangerous substances
|Broad subject area(s)
Occupational exposure limits