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Document ID (ISN)75301
CIS number 00-1080
ISBN(s) 90-5549-290-6
Year 1999
Convention or series no. Gezondheidsraad publication 1999/04OSH
Author(s)
Dutch Expert Committee on Occupational Standards (DECOS)
Title Azathioprine - Health-based calculated occupational cancer risk values
Bibliographic information Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 32p. 11 ref.
Abstract Azathioprine is an immunosupressant. Main tumours in human after treatment with azathioprine include non-Hodgkin's lymphoma, squamous cell cancers of the skin, hepatobiliary carcinomas and mesenchymal tumours. Additional lifetime cancer risk for azathioprine amounts to 4 x 10-5 for 40 years of occupational exposure to 0.005mg/m3, and 4 x 10-3 for 40 years of occupational exposure to 0.5mg/m3. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (toxic effect: bone-marrow depression). Summary in Dutch.
Descriptors (primary) threshold limit values; carcinogens; toxicology; azathioprine; Netherlands
Descriptors (secondary) toxicity evaluation; criteria document; carcinogenic effects
Document type B - Chemical safety information sheets
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Heterocyclic compounds
Occupational exposure limits