| Document ID (ISN) | 75301 |
| CIS number |
00-1080 |
| ISBN(s) |
90-5549-290-6 |
| Year |
1999 |
| Convention or series no. |
Gezondheidsraad publication 1999/04OSH
|
| Author(s) |
Dutch Expert Committee on Occupational Standards (DECOS) |
| Title |
Azathioprine - Health-based calculated occupational cancer risk values |
| Bibliographic information |
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 32p. 11 ref. |
| Abstract |
Azathioprine is an immunosupressant. Main tumours in human after treatment with azathioprine include non-Hodgkin's lymphoma, squamous cell cancers of the skin, hepatobiliary carcinomas and mesenchymal tumours. Additional lifetime cancer risk for azathioprine amounts to 4 x 10-5 for 40 years of occupational exposure to 0.005mg/m3, and 4 x 10-3 for 40 years of occupational exposure to 0.5mg/m3. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (toxic effect: bone-marrow depression). Summary in Dutch. |
| Descriptors (primary) |
threshold limit values; carcinogens; toxicology; azathioprine; Netherlands |
| Descriptors (secondary) |
toxicity evaluation; criteria document; carcinogenic effects |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | Netherlands |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Occupational exposure limits
Heterocyclic compounds
|
