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Document ID (ISN)75224
CIS number 00-1052
ISSN - Serial title 0465-546X - Medicina y seguridad del trabajo
Year 1997
Convention or series no.
Author(s) Robert A., Ducos P., Francin J.M.
Title Assessment of occupational exposure to 4,4'-methylenedianiline (MDA) in France
Original title Evaluación de la exposición profesional a la 4,4-metilendianilina (MDA) en Francia [in Spanish]
Bibliographic information 1997, Vol.XLIV, No.173, p.1-11. 35 ref.
Abstract Translation of an article originally published in the French journal Cahiers de notes documentaires - Hygične et sécurité du travail, 4th Quarter 1996, No.165, Note No.2032-165-96 (see CIS 97-173). Contents: Methylenedianiline (MDA), a suspected human carcinogen in the European carcinogen classification system, is used in a number of industrial sectors in conjunction with resins and composite materials. Exposure to MDA was assessed in workers in 10 French firms by measuring urinary MDA excretion levels. Analysis of 368 post-shift urine samples collected from 133 workers reveals that urinary excretion of MDA is much higher in workers handling flaked MDA than in those handling MDA in solution (44% and 8% of values, respectively, in excess of 50µg/L). The mean rates were 140µg/L for the factories using flaked MDA and 13µg/L for the 6 factories using liquid formulations, with values ranging from 58 to 197µg/L and from <2 to 33µg/L respectively. Simple modifications of working practices can greatly reduce the urinary excretion levels, especially in workers handling flaked MDA. The usefulness of biological monitoring for following up exposed workers and assessing preventive measures is stressed. In the light of the current technical and analytical possibilities in France, it is recommended to reduce the present biological guide value used by industrial hygienists from 100µg/L down to 50µg/L.
Descriptors (primary) carcinogens; exposure evaluation; France; methylenedianiline
Descriptors (secondary) urine monitoring; high-pressure liquid chromatography; translation
Document type D - Periodical articles
Country / State or ProvinceSpain
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Aromatic amines