| Document ID (ISN) | 74903 |
| CIS number |
00-802 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Sorahan T., Hamilton L., Jackson J.R. |
| Title |
A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special reference to the chemicals 2-mercaptobenzothiazole (MBT), aniline, phenyl-β-naphthylamine and o-toluidine |
| Bibliographic information |
Feb. 2000, Vol.57, No.2, p.106-115. Illus. 30 ref. |
| Abstract |
Mortality (1955-1996) and cancer morbidity (1971-1992) of a cohort of 2,160 male production workers from a chemical factory in north Wales were investigated. All subjects had at least 6 months employment at the factory and some employment in the period 1955-84. Detailed job histories were abstracted from company computerized records and estimates of individual cumulative exposure to 2-mercaptobenzothiazole (MBT) and its derivatives were obtained, with a job exposure matrix derived by a former factory hygienist. Durations of employment in the aniline, phenyl-β-naphthylamine (PBN) and o-toluidine departments were also calculated. Findings suggest that some members of this cohort have had occupational bladder cancer. The simplest interpretation of the findings about bladder cancer may be that PBN (or a chemical reagent or chemical intermediate associated with its production at this factory in the 1930s and 1940s) is a bladder carcinogen. |
| Descriptors (primary) |
carcinogens; rubber industry; cancer; chemical products; mortality |
| Descriptors (secondary) |
benzotriazole; naphthylamines; o-toluidine; frequency rates; bladder tumour; cohort study; long-term study; aniline |
| Document type |
D - Periodical articles |
| Country / State or Province | United Kingdom |
| Subject(s) |
Chemicals, plastics and rubber
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Rubber industry
|
