|Document ID (ISN)||74355|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Heederik D., Doekes G., Nieuwenhuijsen M.J.
||Exposure assessment of high molecular weight sensitisers: Contribution to occupational epidemiology and disease prevention
||Nov. 1999, Vol.56, No.11, p.735-741. Illus. 52 ref.
||Because exposure to high molecular weight sensitizers could only be evaluated indirectly, few studies have focused on establishing exposure-response relations, and exposure standards have not been established for high molecular weight sensitizers. Epidemiological studies in several industries that used immunoassay for exposure characterization have shown that risk of sensitization increases with increasing exposure to allergens. Several studies have also shown that clear differences in potency seem to exist. Sensitization to rat urinary allergens and fungal α-amylase occurred in the pg/m3 and ng/m3 range. The main research questions of the near future have to focus on the prevention of occupational sensitization. Standard-setting seems possible for some allergens on the basis of available scientific evidence for the existence of exposure response relations. However, assays for characterising exposure to allergens have to be rigorously standardized before they can be used under field conditions.
||epidemiology; occupational medicine; immunobiological changes; sensitizers
||Aspergillus moulds; allergens; dose-response relationship; amylase; glycoproteins; immunoglobulins
||D - Periodical articles
|Country / State or Province||United Kingdom; Netherlands|
|Broad subject area(s)
||Occupational medicine, epidemiology