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CISDOC database

Document ID (ISN)74242
CIS number 00-174
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Dell L.D., Mundt K.A., McDonald M., Tritschler J.P., Mundt D.J.
Title Critical review of the epidemiology literature on the potential cancer risks of methylene chloride
Bibliographic information Oct. 1999, Vol.72, No.7, p.429-442. 40 ref.
Abstract Literature survey with the aim of critically reviewing and summarizing the epidemiological evidence published to date on the carcinogenicity of dichloromethane to humans. Papers for review were identified through the US National Library of Medicine's Medline. Studies were classified according to three categories. Primary studies focused on the association between dichloromethane and cancer among occupational cohorts primarily exposed to dichloromethane. Secondary studies identified dichloromethane a priori as a potential exposure of interest, and which was either characterized or described for exposed workers separately. Tertiary studies evaluated cohorts either minimally exposed or presumed exposed to dichloromethane but for which no exposure estimation or separate classification was made. Continued follow-up of the established cohorts may elucidate the few and inconsistent relationships reported to date. However, it appears likely that risks associated with exposure, if any, are small and limited to rare cancers.
Descriptors (primary) carcinogens; cancer; epidemiology; dichloromethane
Descriptors (secondary) literature survey
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons
Epidemiology